Abstract
The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide
Copyright 2002 Elsevier Science Ireland Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / metabolism*
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Blood Glucose / metabolism
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Body Weight / drug effects
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Catalase / metabolism
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Cucurbitaceae / chemistry*
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Diabetes Mellitus, Experimental / metabolism*
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Ethanol
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Glutathione / blood
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Glutathione Peroxidase / blood
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Glutathione Transferase / blood
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Hydrogen Peroxide / metabolism
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Insulin / blood
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Lipid Peroxides / metabolism
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Male
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Rats
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Rats, Wistar
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Solvents
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Superoxide Dismutase / blood
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Thiobarbituric Acid Reactive Substances / metabolism
Substances
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Antioxidants
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Blood Glucose
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Insulin
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Lipid Peroxides
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Plant Extracts
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Solvents
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Thiobarbituric Acid Reactive Substances
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Ethanol
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Hydrogen Peroxide
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Catalase
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Glutathione Peroxidase
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Superoxide Dismutase
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Glutathione Transferase
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Glutathione