Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats

J Ethnopharmacol. 2003 Feb;84(2-3):163-8. doi: 10.1016/s0378-8741(02)00294-5.

Abstract

The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Catalase / metabolism
  • Cucurbitaceae / chemistry*
  • Diabetes Mellitus, Experimental / metabolism*
  • Ethanol
  • Glutathione / blood
  • Glutathione Peroxidase / blood
  • Glutathione Transferase / blood
  • Hydrogen Peroxide / metabolism
  • Insulin / blood
  • Lipid Peroxides / metabolism
  • Male
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Rats
  • Rats, Wistar
  • Solvents
  • Superoxide Dismutase / blood
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Antioxidants
  • Blood Glucose
  • Insulin
  • Lipid Peroxides
  • Plant Extracts
  • Solvents
  • Thiobarbituric Acid Reactive Substances
  • Ethanol
  • Hydrogen Peroxide
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Transferase
  • Glutathione