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Arch Androl. 2003 Jan-Feb;49(1):49-55.

Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss.

Author information

1
Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. dcarrell@med.utah.edu

Abstract

Previous studies have indicated that sperm quality may be related to unexplained recurrent pregnancy loss. This study evaluated the degree of sperm DNA fragmentation using the TUNEL assay on sperm from 24 couples with unexplained recurrent pregnancy loss (RPL) compared to sperm from 2 control groups: donors of known fertility and unscreened men from the general population. The percentage of sperm staining positive for DNA fragmentation was increased (p < .001) in the RPL group (38 +/- 4.2) compared to the donor (11.9 +/- 1.0) or general population (22 +/- 2.0) control groups. In the RPL group, no correlation was observed between semen quality parameters and the TUNEL data. These data indicate that some RPL patients have a significant increase of sperm DNA fragmentation, which may be causative of pregnancy loss in some patients.

PMID:
12647778
DOI:
10.1080/01485010290099390
[Indexed for MEDLINE]

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