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Biol Cybern. 2003 Mar;88(3):229-35.

Dynamical synaptic plasticity: a model and connection to some experiments.

Author information

1
Institute for Nonlinear Science, University of California, San Diego 92093-0402, USA.

Abstract

Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745-755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.

PMID:
12647230
DOI:
10.1007/s00422-002-0376-4
[Indexed for MEDLINE]

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