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Nat Cell Biol. 2003 Mar;5(3):179-82.

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

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1
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. mb2@mrc-lmb.cam.ac.uk

Abstract

Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.

PMID:
12646868
DOI:
10.1038/ncb0303-179
[Indexed for MEDLINE]
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