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Ophthalmic Res. 2003 Mar-Apr;35(2):97-101.

Penetration of levofloxacin into human aqueous humor.

Author information

1
First Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan. covanet@aol.com

Abstract

This study was designed to measure the concentration of levofloxacin in aqueous humor after topical and oral administration in patients undergoing cataract extraction. Patients were randomly divided into four groups. Levofloxacin concentration in the aqueous humor was the highest in the group in which 600 mg was given orally plus five topical instillations before surgery. The aqueous humor levels of levofloxacin after topical and oral administration exceeded the minimum inhibitory concentrations for certain bacterial species that frequently cause intraocular infection.

PMID:
12646750
DOI:
10.1159/000069128
[Indexed for MEDLINE]

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