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Curr Biol. 2003 Mar 18;13(6):R239-41.

Receptor sensitivity: when T cells lose their sense of self.

Author information

1
University of Minnesota, Center for Immunology, 312 Church Street, S.E., Minneapolis, Minnesota 55455, USA. hogqu001@umn.edu

Abstract

The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.

PMID:
12646152
DOI:
10.1016/s0960-9822(03)00161-1
[Indexed for MEDLINE]
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