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Curr Biol. 2003 Mar 18;13(6):R231-3.

Fragile sites: breaking up over a slowdown.

Author information

  • 1Stanford University, Department of Molecular Pharmacology, Stanford, CA 94305-5174, USA. cimprich@stanford.edu

Abstract

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

PMID:
12646149
[PubMed - indexed for MEDLINE]
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