Format

Send to

Choose Destination
J Med Chem. 2003 Mar 27;46(7):1120-2.

Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase.

Author information

1
Ontogen Corporation, 6451 El Camino Real, Carlsbad, California 92009, USA. Debbie.slee@ontogen.com

Abstract

The regulation of lipid metabolism and it's effect on glucose control and diabetes has received intense interest. Hormone-sensitive lipase (HSL) is a vital enzyme in lipid metabolism. A series of novel pyrrolopyrazinediones has been discovered that demonstrate submicromolar activity both in the enzyme assay and in a (14)C-emulsion assay employing cholesteryl oleate as a substrate as a secondary measure of HSL activity. These compounds represent novel inhibitors of the human HSL enzyme.

PMID:
12646020
DOI:
10.1021/jm020460y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center