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Bioorg Med Chem Lett. 2003 Mar 24;13(6):1133-6.

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, PO 4000, Princeton, NJ 08543-4000, USA.

Abstract

1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro. In cells 3 acts as a cytotoxic agent with the ability to block cell cycle progression and/or induce apoptosis. The solid state structure of 3 bound to CDK2 shows 3 resides coincident with the ATP purine binding site and forms important H-bonding interactions with Leu83 on the protein backbone.

PMID:
12643928
DOI:
10.1016/s0960-894x(03)00034-9
[Indexed for MEDLINE]

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