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Bioorg Med Chem Lett. 2003 Mar 24;13(6):1051-4.

Substituted 4-methylquinolines as a new class of anti-tuberculosis agents.

Author information

1
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India. rahuljain@niper.ac.in

Abstract

We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series 3d (MIC=6.25 microg/mL, Mycobacterium tuberculosis H37Rv strain) was synthesized in one step; thus is an attractive lead molecule for anti-tuberculosis drug development. The results of this study represent the discovery of ring-substituted 4-methylquinolines as new class of potential anti-tuberculosis agents.

PMID:
12643909
DOI:
10.1016/s0960-894x(03)00074-x
[Indexed for MEDLINE]

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