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Dig Liver Dis. 2002 Dec;34(12):842-5.

Genetic dissection between silent and clinically diagnosed symptomatic forms of coeliac disease in multiplex families.

Author information

1
Medical School Paediatric Research Centre, University of Tampere, Finland.

Abstract

BACKGROUND:

Coeliac disease has a large variation in clinical outcome. In addition to the classical disease with malabsorption, many individuals have a silent form, in which subject symptoms are missing but autoantibodies and mucosa lesions are identical to the symptomatic disease.

AIM:

To investigate whether differences in HLA DR-DQ genes explain the variation in outcome.

MATERIALS AND METHODS:

HLA DQ alleles were determined in 28 multiplex families with sibling pairs in which one had the symptomatic disease but the other had the silent form.

RESULTS:

No differences in the distribution of HLA DR-DQ haplotypes could be observed. The clinically diagnosed coeliac disease seemed to have earlier onset than silent coeliac disease.

CONCLUSIONS:

Results indicate that the major genetic susceptibility locus, HLA DQ, does not determine the exact clinical outcome of coeliac disease.

PMID:
12643291
[Indexed for MEDLINE]

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