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Bioorg Med Chem Lett. 2003 Feb 24;13(4):729-32.

Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors.

Author information

1
Department of Medicinal Chemistry, Millennium Pharmaceuticals Inc., 256 East Grand Avenue, South San Francisco, CA 94080, USA.

Abstract

The structure-activity relationship of a novel series of substituted piperazinone-based factor Xa inhibitors is described. The most potent compound 34 displays IC(50) of 0.9 nM.

PMID:
12639568
DOI:
10.1016/s0960-894x(02)01038-7
[Indexed for MEDLINE]

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