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Bioorg Med Chem Lett. 2003 Feb 24;13(4):701-4.

Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.

Author information

1
Neurogen Corporation, 35 Northeast Industrial Road, Branford, CT 06405, USA. hzhao@nrgn.com

Abstract

5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D(2)/D(4) receptor antagonists. This series featured a rigid tricyclic ring system as an important pharmacophore core structure for high binding affinity. Molecular modeling studies are also described.

PMID:
12639562
DOI:
10.1016/s0960-894x(02)01056-9
[Indexed for MEDLINE]

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