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J Am Acad Dermatol. 2003 Mar;48(3):352-8.

Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis.

Author information

1
Division of Special and Environmental Dermatology, Department of Dermatology, University of Vienna Medical School, Austria. paul.sator@khl.magwien.gv.at

Abstract

BACKGROUND:

The water content of the stratum corneum and skin surface lipids are important factors in the appearance and function of the skin. A disruption of the balance between the two may lead to the clinical manifestation of dryness of skin in patients with atopic dermatitis.

OBJECTIVE:

The aim of our study was to examine the so-called dry skin of patients with atopic dermatitis using objective parameters. We compared the epidermal hydration and the skin surface lipids, the so-called hydro-lipid film, of the clinically unaffected skin of patients suffering from atopic dermatitis with that of healthy subjects.

METHODS:

A total of 48 patients of either gender were included in this retrospective case-control study. We used the Corneometer CM 820 (Courage+Khazaka Electronic GmbH, Cologne, Germany) and the Sebumeter SM 810 (Courage+Khazaka Electronic GmbH) as noninvasive measuring methods.

RESULTS:

The results showed marked decreases in the atopic dermatitis group for both the Corneometer and Sebumeter measuring methods.

CONCLUSION:

Our results show that the dry skin of patients with atopic dermatitis, as previously shown, is due not only to a decrease in skin moisture but also to a reduction of skin lipids. This finding gives rise to a new understanding of the condition, and therefore one should always speak of a hydro-lipid film.

PMID:
12637914
DOI:
10.1067/mjd.2003.105
[Indexed for MEDLINE]
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