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Dev Cell. 2003 Mar;4(3):289-90.

Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast.

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1
Institut Curie, UMR144 du CNRS, 26 rue d'Ulm, 75248 Paris Cedex 05, France.

Abstract

In the February 21 issue of Cell, demonstrate that asymmetrical loading of Kar9 onto astral microtubules (MTs) emanating from the bud-ward-directed spindle pole ensures delivery of this spindle pole to the bud. Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud.

PMID:
12636909
[Indexed for MEDLINE]
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