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Nat Rev Cancer. 2002 Feb;2(2):83-90.

Specialization of tumour vasculature.

Author information

1
Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. ruoslahti@burnham.org

Abstract

Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and their extracellular matrix. These special features of tumour vessels are good targets for cancer therapies.

PMID:
12635171
DOI:
10.1038/nrc724
[Indexed for MEDLINE]

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