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Hautarzt. 2003 Mar;54(3):209-14. Epub 2003 Feb 12.

[Latest aspects in psoriasis pathogenesis].

[Article in German]

Author information

1
Klinik und Poliklinik für Dermatologie und Allergologie der LMU München, Munich. joerg.prinz@lrz.uni-muenchen.de

Abstract

During recent years the understanding of psoriasis pathogenesis has changed essentially. Psoriasis is now considered as a T cell mediated inflammation of the skin. Genetic predisposition and microbial environment cooperate in the induction of an antigen-specific T cell mediated immune response which may persist lifelong. The phenotype of the psoriatic inflammation is determined by the particular functional differentiation of the pathogenic T cells. The progress in understanding the pathogenesis of psoriasis has identified T cells and T cell-derived cytokines as targets for causal treatment approaches that in the near future will change psoriasis therapy considerably.

PMID:
12634988
DOI:
10.1007/s00105-003-0490-9
[Indexed for MEDLINE]
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