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Curr Opin Immunol. 2003 Apr;15(2):158-65.

B-cell commitment: deciding on the players.

Author information

1
Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. rr_hardy@fccc.edu

Abstract

Considerable progress has been made over the past few years in determining the key molecular players that regulate the commitment and development of early B-lineage cells in mouse bone marrow (transcription factors, cytokines and their receptors). However, confusion remains as to the precise stages, surface phenotypes and lineage restrictions that are observed early in B-cell development. Increasingly powerful flow cytometry analysis of genetically altered animals (knockouts and transgenics) combined with sensitive functional assays may provide an answer, a "scorecard" for the cell stages.

PMID:
12633665
DOI:
10.1016/s0952-7915(03)00012-8
[Indexed for MEDLINE]

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