Format

Send to

Choose Destination
See comment in PubMed Commons below
Sci STKE. 2003 Mar 11;2003(173):pe10.

Cellular distribution of Bcl-2 family proteins.

Author information

1
Department of Biochemistry, McGill University, Montréal, Québec, H3G 1Y6, Canada.

Abstract

Proteins synthesized in the cytosol can be inserted into or across organellar membranes depending on the signals present in their primary sequences. Proteins of the Bcl-2 family, which includes proteins that promote programmed cell death (apoptosis) and proteins that inhibit apoptosis, have signals that can target particular members to either the mitochondria or the endoplasmic reticulum (ER) or both. Germain and Shore discuss evidence for a role for the anti-apoptotic members of the family at the ER and describe an interaction with the FK506 binding protein, FKBP38, that may regulate the relative distribution of Bcl-2 proteins at the ER or mitochondria. This interaction may control the cell's sensitivity to apoptotic stimuli.

PMID:
12631689
DOI:
10.1126/stke.2003.173.pe10
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center