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Phys Med Biol. 2003 Feb 21;48(4):417-27.

Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation.

Author information

1
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. chenyu@mail.med.upenn.edu

Abstract

We measure the tissue oxygen and haemoglobin concentrations in the rat brain during modulation of inhaled oxygen concentration (FiO2), using non-invasive frequency domain near-infrared oximetry. The rise in oxygenated haemoglobin concentration and the decline in deoxygenated haemoglobin concentration are demonstrated in correspondence with the modulation of FiO2, which is changed from 20% to 100% in increments of 20%. Furthermore, the tissue oxygenation saturation also shows the corresponding trend and changes ranging from approximately 70% to 90%. The relative changes in deoxygenated haemoglobin concentration are compared to the blood-oxygenation-level-dependent (BOLD) MRI signal recorded during a similar FiO2 protocol. A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed.

PMID:
12630739
[Indexed for MEDLINE]

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