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BJOG. 2003 Mar;110(3):306-10.

Maternal serum activin A levels in association with intrauterine fetal growth restriction.

Author information

1
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Victoria, Clayton, Australia.

Abstract

OBJECTIVE:

To assess maternal serum activin A as a potential marker of fetal growth restriction.

DESIGN:

A cohort study.

SETTING:

A maternal-fetal medicine unit, university teaching hospital.

POPULATION:

Fifty-seven women with a small fetus (less than 10th centile for gestation) referred for assessment of fetal size by ultrasound biometry.

METHODS:

At the time of presentation for fetal biometry, maternal blood was collected for activin A measurement. The case records of each woman were independently reviewed after delivery and the pregnancy grouped into one of three groups: constitutionally small fetus, intrauterine growth restricted (IUGR) fetus or IUGR fetus and maternal pre-eclampsia (IUGR-pre-eclampsia). Activin A levels in the three groups were compared.

MAIN OUTCOME MEASURES:

Maternal serum activin A levels.

RESULTS:

Sixteen of the 57 pregnancies were classified as constitutionally small, 17 as IUGR and 24 as IUGR-pre-eclampsia. Expressed as multiples of a normal median (MoMs), the median (95% CI) activin A level in the constitutionally small pregnancies was 1.12 (0.72-1.39) MoMs significantly lower than the level in both the IUGR pregnancies, 3.00 (1.84-4.11) MoMs, and the IUGR-pre-eclampsia pregnancies, 7.96 (5.73-10.62) MoMs (P = 0.002 and 0.0001 for IUGR vs constitutionally small and IUGR-pre-eclampsia vs constitutionally small, respectively).

CONCLUSIONS:

Maternal serum activin A may be useful in the assessment of the small for gestational age fetus.

PMID:
12628273
[Indexed for MEDLINE]
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