Format

Send to

Choose Destination
Cell. 2003 Mar 7;112(5):599-606.

Polycomb, epigenomes, and control of cell identity.

Author information

1
Dulbecco Telethon Institute, Institute of Genetics & Biophysics CNR, Via Pietro Castellino 111, 80131, Naples, Italy. orlando@iigb.na.cnr.it

Abstract

In development, cell identity is maintained by epigenetic functions that prevent changes in cell type-specific transcription programs. Recent insights into gene silencing mechanisms by Polycomb group (PcG) and trithorax group (trxG) proteins reveal that the memory system involves a concerted process of chromatin modification, blocking of RNA polymerase II, and synthesis of noncoding RNA. Remarkably, cell memory is regulated by a balance between repressors and activators that maintains both transcription status and at the same time the possibility of switching to a different state.

PMID:
12628181
DOI:
10.1016/s0092-8674(03)00157-0
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center