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Cell. 2003 Mar 7;112(5):589-91.

SET-ting the stage for life and death.

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  • 1Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.


Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

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