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Eur J Clin Microbiol Infect Dis. 2003 Feb;22(2):111-3. Epub 2003 Feb 14.

Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine.

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Department of Infectious Diseases, The Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia.


Disseminated Scedosporium prolificans infections are almost uniformly fatal because of their resistance to antifungal agents. Recently, synergy between triazoles and terbinafine has been demonstrated against Scedosporium prolificans in vitro. Reported here is a patient who developed disseminated Scedosporium prolificans infection following bone marrow transplantation and who was successfully treated with a combination of voriconazole and terbinafine in addition to aggressive surgical debridement. Antifungal synergy testing and combination therapy should be considered in cases of disseminated infection with Scedosporium prolificans.

[Indexed for MEDLINE]

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