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Clin Radiol. 2003 Feb;58(2):148-53.

Magnetic resonance spectroscopic abnormalities in sporadic and variant Creutzfeldt-Jakob disease.

Author information

1
Section of Academic Radiology, Royal Hallamshire Hospital, Floor C Glossop Road, Sheffield, UK. Hament@doctors.org.uk

Abstract

AIM:

To study the proton MR spectroscopic findings in Creutzfeldt-Jakob disease (CJD) (sporadic and variant).

MATERIALS AND METHODS:

MR imaging and proton MR spectra were acquired in two patients with sporadic CJD (biopsy proven) and one patient with variant CJD.

RESULTS:

The two patients with sporadic CJD demonstrated MR signal change within the basal ganglia and thalami and reduced N-acetylaspartate (NAA):creatine ratios. The patient with variant CJD showed characteristic signal change within the pulvinar of the thalami and a markedly reduced N-acetylaspartate:creatine ratio.

CONCLUSION:

All three patients with CJD demonstrated evidence of reduced N-acetylaspartate: creatine ratios on MR spectroscopy. These changes imply that neuronal loss and/or dysfunction is a consistent finding in established CJD.

PMID:
12623045
[Indexed for MEDLINE]
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