Abstract
We describe the case of a 61-year-old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [(123)I]N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane and single photon emission computed tomography ([(123)I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.
MeSH terms
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Antiparkinson Agents / therapeutic use
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Dopamine Plasma Membrane Transport Proteins
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Female
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Humans
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Hyponatremia / complications*
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Hyponatremia / therapy
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Isotonic Solutions / therapeutic use
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Levodopa / therapeutic use
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Membrane Glycoproteins*
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Membrane Transport Proteins / metabolism*
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Middle Aged
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Myelinolysis, Central Pontine / diagnostic imaging
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Myelinolysis, Central Pontine / etiology*
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Myelinolysis, Central Pontine / metabolism
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Nerve Tissue Proteins*
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Parkinsonian Disorders / diagnostic imaging
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Parkinsonian Disorders / drug therapy
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Parkinsonian Disorders / etiology*
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Protein Binding
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Radiopharmaceuticals
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Tomography, Emission-Computed, Single-Photon
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Treatment Outcome
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Tropanes
Substances
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Antiparkinson Agents
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Dopamine Plasma Membrane Transport Proteins
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Isotonic Solutions
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Radiopharmaceuticals
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Tropanes
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N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane
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Levodopa