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Cancer Cell. 2003 Feb;3(2):105-10.

Considering the cancer consequences of altered DNA polymerase function.

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Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC 27709, USA.


Our appreciation of the DNA transactions that replicate and maintain a stable human genome is changing rapidly due to recent discoveries indicating that eukaryotic cells contain many more DNA polymerases than previously thought. This review describes emerging information on the properties and functions of human DNA polymerases, with emphasis on connections between DNA polymerase functions and cancer.

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