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Phytochemistry. 2003 Feb;62(3):371-6.

A 2-oxoglutarate-dependent dioxygenase is integrated in DIMBOA-biosynthesis.

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  • 1Lehrstuhl für Genetik, Technische Universität München, 85350 Freising, Germany.


Benzoxazinoids are secondary metabolites of grasses that function as natural pesticides. While many steps of DIMBOA biosynthesis have been elucidated, the mechanism of the introduction of OCH(3)-group at the C-7 position was unknown. Inhibitor experiments in Triticum aestivum and Zea mays suggest that a 2-oxoglutarate-dependent dioxygenase catalyses the hydroxylation reaction at C-7. Cloning and reverse genetics analysis have identified the Bx6 gene that encodes this enzyme. Bx6 is located in the Bx-gene cluster of maize.

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