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Mol Cell. 2003 Feb;11(2):283-4.

Histone deposition at the replication fork: a matter of urgency.

Author information

1
Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Herts, United Kingdom.

Abstract

In this issue of Molecular Cell, Ye et al. provide a biological rationale for rapid histone deposition behind the replication fork. They show that defects in nucleosome assembly lead to DNA double-strand breaks and S phase arrest. Their results have important implications for the maintenance of genome integrity in proliferating cells.

PMID:
12620214
DOI:
10.1016/s1097-2765(03)00052-2
[Indexed for MEDLINE]
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