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J Bacteriol. 2003 Mar;185(6):1911-22.

Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.

Author information

1
Department of Cellular and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

Additional targets of CodY, a GTP-activated repressor of early stationary-phase genes in Bacillus subtilis, were identified by combining chromatin immunoprecipitation, DNA microarray hybridization, and gel mobility shift assays. The direct targets of CodY newly identified by this approach included regulatory genes for sporulation, genes that are likely to encode transporters for amino acids and sugars, and the genes for biosynthesis of branched-chain amino acids.

PMID:
12618455
PMCID:
PMC150151
[Indexed for MEDLINE]
Free PMC Article

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