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Cancer Lett. 2003 Mar 10;191(2):187-91.

Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.

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Department of Biology and Genetics, Medical Faculty, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.


The aim of the study was to explore a possible association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cervical neoplasia. A total of 229 women were subjected to cytologic and colposcopic evaluation. Ninety-one of them were found to be normal, and served as the control group, while the other 138 of them had present or past histologically proven cervical pathology (patients group). All patients and controls were investigated for the MTHFR C677T polymorphism. Statistical analysis between the groups of cases with cervical intraepithelial neoplasia or invasive cervical cancer and the control group did not reveal any statistically significant difference in the frequency of the MTHFR C677T polymorphism.

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