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Chem Biol. 2003 Feb;10(2):101-3.

Mammalian fatty acid synthase: closure on a textbook mechanism?

Author information

1
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

Abstract

Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh evidence has upset this view.

PMID:
12618179
[Indexed for MEDLINE]

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