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Bioorg Med Chem Lett. 2003 Mar 10;13(5):881-4.

Synthesis and anticancer effect of chrysin derivatives.

Author information

1
College of Chemistry and Chemical Engineering, Donghua Unversity, 1882 West Yanan Lu, Shanghai 200051, PR, China.

Abstract

A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells.

PMID:
12617913
DOI:
10.1016/s0960-894x(02)01081-8
[Indexed for MEDLINE]

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