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Acta Pharmacol Sin. 2003 Mar;24(3):207-11.

Fructose diet and VEGF-induced plasma extravasation in hamster cheek pouch.

Author information

1
Département Diabète et Maladies Métaboliques Institut de Recherches Servier, 92150 Suresnes, France. michel.feletou@fr.ntgrs.com

Abstract

AIM:

To determine in the hamster cheek pouch whether or not the changes in plasma extravasation induced by vascular endothelial growth factor (VEGF) could be affected by fructose diet.

METHODS:

Hamsters were subjected to control drinking water or to water containing fructose (10 %) for 18 weeks.

RESULTS:

The fructose diet induced a small but significant increase in glycemia (0.80+/-0.11 and 1.09+/-0.15, n=8 and 9 for control and fructose- treated animals, respectively, P<0.05). Bradykinin-induced plasma extravasation was not affected by the fructose diet while the effects of VEGF were markedly increased (maximal number of leakage sites: 76+/-20 and 126+/-55, n = 8 and 9 for control and fructose-treated animals, respectively, P<0.01).

CONCLUSION:

Even moderate changes in glycemic levels can produce profound alteration in the VEGF response.

PMID:
12617767
[Indexed for MEDLINE]
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