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J Antimicrob Chemother. 2003 Mar;51(3):497-511.

Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide.

Author information

1
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstrasse 24, 04103 Leipzig, Germany. ackermg@medizin.uni-leipzig.de

Abstract

Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides do not induce macrolide-lincosamide-streptogramin B (MLS(B)) resistance and are active against erythromycin resistance methylase gene (erm)-carrying Gram-positive cocci. This review summarizes published data on telithromycin and intends to define the challenge that a new antimicrobial brings to medical practice.

PMID:
12615850
DOI:
10.1093/jac/dkg123
[Indexed for MEDLINE]

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