Format

Send to

Choose Destination
Br J Psychiatry. 2003 Mar;182:210-3.

Effects of a branched-chain amino acid drink in mania.

Author information

1
University of Oxford, Warneford Hospital, UK. anna.scarna@psych.ox.ac.uk

Abstract

BACKGROUND:

Administration of a complex tyrosine-free amino acid drink acutely decreases manic symptoms. Although a nutrient-based approach to illness management is attractive, complex amino acid drinks are too unpalatable for repeated administration.

AIMS:

To assess whether a simple, branched-chain amino acid (BCAA) drink diminishes manic symptoms acutely and following repeated administration.

METHOD:

Twenty-five patients with mania were randomly and blindly allocated to treatment with BCAA (60 g) or placebo daily for 7 days.

RESULTS:

Relative to placebo, the BCAA drink lowered mania ratings acutely over the first 6 h of treatment. In protocol completers there was a persistent advantage to the BCAA group 1 week after the end of treatment.

CONCLUSIONS:

A nutritional intervention that decreases tyrosine availability to the brain acutely ameliorates manic symptoms. Further studies are required to assess whether this approach has longer-term efficacy.

PMID:
12611783
DOI:
10.1192/bjp.182.3.210
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center