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Microcirculation. 2003 Jan;10(1):5-25.

Florence Sabin and the mechanism of blood vessel lumenization during vasculogenesis.

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1
Department of Anatomy, University of Wisconsin-Madison Medical School, Madison, WI 53706, USA. kdowns@facstaff.wisc.edu

Abstract

The notion that blood vessel lumina and primordial blood plasma are linked by a single mechanism, intracellular vacuolation of angioblasts, has, for the most part, been overlooked since it was first described in the early decades of the last century. That vacuolation may play a major role in blood vessel formation during vasculogenesis is revisited from the perspective of Florence Sabin's seminal studies in the nascent mesoderm of living chick blastoderms.

PMID:
12610661
DOI:
10.1038/sj.mn.7800171
[Indexed for MEDLINE]
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