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Br J Cancer. 2003 Jan 27;88(2):206-9.

Transcriptional impairment of beta-catenin/E-cadherin complex is not associated with beta-catenin mutations in colorectal carcinomas.

Author information

1
Nursing Military Academy, Laboratory of Research, Athens, Greece. garinis@gen.fgg.eur.nl

Abstract

We report the absence of beta-catenin mutations in 63 sporadic colorectal carcinomas (SCRCs) with demonstrated decreased beta-catenin and E-cadherin mRNA expression and E-cadherin protein expression in a subset of carcinomas examined, suggesting that beta-catenin mutations are an extremely rare phenomenon in SCRCs and are not responsible for the transcriptional impairment of the beta-catenin/E-cadherin adhesion complex observed in these tumours.

PMID:
12610504
PMCID:
PMC2377055
DOI:
10.1038/sj.bjc.6600706
[Indexed for MEDLINE]
Free PMC Article

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