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Br J Cancer. 2003 Jan 27;88(2):163-6.

Endothelin-1: a multifunctional molecule in cancer.

Author information

1
Department of Surgery, Royal Free and University College London Medical School, UK.

Abstract

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.

PMID:
12610497
PMCID:
PMC2377061
DOI:
10.1038/sj.eye.6700750
[Indexed for MEDLINE]
Free PMC Article
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