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Microbiol Res. 2003;158(1):55-8.

Overexpression and increased DNA topoisomerase II-like enzyme activity in arsenite resistant Leishmania donovani.

Author information

1
Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160062, India.

Abstract

Western immunoblot analyses of whole cell lysates probed with a human specific monoclonal anti-topoisomerase IIalpha antibody identified a 190 kDa protein over expressed in the arsenite resistant Leishmania donovani strain. The crude nuclear extract of the resistant strain showed higher topoisomerase II-like enzyme activity. suggesting a possible regulatory role of putative topoisomerase II in arsenite resistant Leishmania.

PMID:
12608580
DOI:
10.1078/0944-5013-00177
[Indexed for MEDLINE]
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