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Hum Genet. 2003 May;112(5-6):617-8. Epub 2003 Feb 27.

No evidence of fetal DNA persistence in maternal plasma after pregnancy.

Author information

1
Department of Obstetrics and Gynecology, H. San Raffaele, Milano, Italy.

Abstract

Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular microchimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

PMID:
12607116
DOI:
10.1007/s00439-003-0919-3
[Indexed for MEDLINE]

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