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Oncogene. 2003 Feb 27;22(8):1243-6.

LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.

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Division of Human Cancer genetics, The Ohio Stsate University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA.


Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung adenocarcinomas and large cell carcinomas containing a Kras2 mutation exhibited allelic loss of the wild-type Kras2 allele when a correlation between LOH of the region on chromosome 12p and Kras2 mutation was made. These results from human lung cancer tissues provide a strong evidence in support of our previous observation in mouse models that the wild-type Kras2 is a tumor suppressor of lung cancer.

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