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Hum Pathol. 2003 Jan;34(1):95-8.

Recurrence of lymphangioleiomyomatosis after single lung transplantation: new insights into pathogenesis.

Author information

1
Institute of Pathology and Institute of Forensic Medicine, Ludwig-Maximilians University, Munich, Germany.

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of childbearing age. The present study describes a case of recurrent LAM after single lung transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry, and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions originated from the recipient. The data strongly support that metastatic spread of LAM cells or migration of progenitor cells plays an important role in the pathogenesis of LAM.

PMID:
12605373
DOI:
10.1053/hupa.2003.50
[Indexed for MEDLINE]

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