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Exp Clin Endocrinol Diabetes. 2003 Feb;111(1):2-7.

Leptin resistance - or why leptin fails to work in obesity.

Author information

1
Department of Endocrinology and Metabolism, Otto-Von-Guericke University, Magdeburg, Germany.

Abstract

In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.

PMID:
12605342
DOI:
10.1055/s-2003-37492
[Indexed for MEDLINE]

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