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Ann Epidemiol. 2003 Mar;13(3):189-95.

Anti-oxidized LDL antibodies and wine consumption: a population-based epidemiological study in Dicomano, Italy.

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1
Department of Critical Care Medicine and Surgery, Section of Gerontology and Geriatric Medicine, University of Florence and Azienda Ospedaliera Careggi, Florence, Italy. mdibari@wfubmc.edu

Abstract

PURPOSE:

In previous studies, higher levels of oxidized low-density lipoprotein (ox-LDL) have been reported to increase the risk of cardiovascular disease. Furthermore, the anti-oxidative properties of red wine have been invoked to explain the paradox of low cardiovascular mortality, in spite of high-fat intake, in the French population. However, the distribution of ox-LDL-antibodies (ox-LDL-Ab) in the unselected population and its relationship with red wine consumption are unknown. This study was carried out to identify factors associated with ox-LDL-Ab, with particular emphasis on the association with wine consumption.

METHODS:

We performed a cross-sectional study of 551 unselected, community-dwelling older adults (aged 65 to 94 years) living in Dicomano (Italy). Ox-LDL-Ab titre was measured with an ELISA method.

RESULTS:

In the whole study sample, ox-LDL-Ab increased with age and was unrelated to blood lipids, HbA(1c), and smoking habit. A significant inverse relationship was found between ox-LDL-Ab titre and daily wine intake, which persisted after adjusting for possible confounders or in subgroup analyses of participants who reported to drink wine or were free from significant morbidity.

CONCLUSIONS:

These results suggest that wine affects ox-LDL-Ab titre in older populations, possibly because of its antioxidant properties.

PMID:
12604163
[Indexed for MEDLINE]
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