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Ann Neurol. 2003 Mar;53(3):390-1.

Seizure exacerbation associated with inhibition of progesterone metabolism.

Author information

1
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Abstract

The reduced progesterone metabolite tetrahydroprogesterone is a potent positive modulator of GABA(A) chloride conductance that exerts powerful neuroinhibitiory and anti-seizure effects in animal models. Cyclic natural progesterone use may lessen seizure frequency in women with catamenial seizure exacerbation. We report a case in which efficacy was eliminated during concomitant treatment with a reductase inhibitor. The observation suggests that a reduced metabolite, rather than progesterone itself, was responsible for improved seizure control.

PMID:
12601707
DOI:
10.1002/ana.10508
[Indexed for MEDLINE]

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