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Cell. 2003 Feb 21;112(4):507-17.

Membrane domains in the secretory and endocytic pathways.

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Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.


Progress in identifying, characterizing, and localizing the constituents of distinct membrane bound compartments has revealed a new level of intracellular subcompartmentation. Proteins and lipids are not uniformly distributed in a given organelle, and subdomains are formed by a combination of hierarchical assembly processes and protein exclusion. Thus, functionally distinct specializations of a given organelle are physically segregated to a greater extent than previously believed.

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