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Hua Xi Yi Ke Da Xue Xue Bao. 2001 Jun;32(2):315-6, 324.

[The photostability of hydrocortisone injection].

[Article in Chinese]

Author information

1
School of Pharmacy, WCUMS, Chengdu 610041, China.

Abstract

OBJECTIVE:

This experiment was designed to make known wether the photostability of drugs in daylight can be obtained from lamplight exposure.

METHODS:

A self made cumulative illuminometer via pulse counting method was used for measuring cumulative illuminance of daylight to investige the photodegradation of Hydrocortisone injection in various lamp light and daylight; the equivalent influences of different light sources on the photostability of the injection were obtained, and the shelf-life in indoor daylight of the drug was predicted.

RESULTS:

The photodegradation of Hydrocortisone injection obeys zero order kinetics: C = C0-kEt; the shelf-life in indoor daylight of the injection in nude ampoules was predicted as 36 days and is comparable to 35 days in a long-term storage test.

CONCLUSION:

The photostability of drugs in daylight can be obtained from lamplight exposure experiment.

PMID:
12600120
[Indexed for MEDLINE]

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