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AIDS. 2003 Mar 7;17(4):625-8.

Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae.

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1
Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada.

Abstract

Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.

[Indexed for MEDLINE]

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