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AIDS. 2003 Mar 7;17(4):625-8.

Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae.

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Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada.


Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.

[Indexed for MEDLINE]

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