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Trends Microbiol. 2003 Feb;11(2):94-100.

Bacterial coaggregation: an integral process in the development of multi-species biofilms.

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School of Pharmacy, University of Manchester, Coupland III Building, Oxford Road, Manchester M13 9PL, UK.


Coaggregation is a process by which genetically distinct bacteria become attached to one another via specific molecules. Cumulative evidence suggests that such adhesion influences the development of complex multi-species biofilms. Once thought to occur exclusively between dental plaque bacteria, there are increasing reports of coaggregation between bacteria from other biofilm communities in several diverse habitats. A general role for coaggregation in the formation of multi-species biofilms is discussed.

[Indexed for MEDLINE]

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